Hydrogen chloride-ethyl acetate → 2-(2-Henicosyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-ethanamine monohydrochloride

HRID 1532687Notes

Reaction equation

HRID 1532687 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([C:29]1[N:33]([CH2:34][CH2:35][N:36]([CH3:38])[CH3:37])[C:32]2[CH:39]=[CH:40][CH:41]=[CH:42][C:31]=2[N:30]=1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C(OCC)(=O)C>[ClH:1].[CH2:8]([C:29]1[N:33]([CH2:34][CH2:35][N:36]([CH3:37])[CH3:38])[C:32]2[CH:39]=[CH:40][CH:41]=[CH:42][C:31]=2[N:30]=1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 220137572-(2-Henicosyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-ethanamine

Product 1

HCID 220137562-(2-Henicosyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-ethanamine monohydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.44 ml) was added to a solutior containing 2-(2-henicosyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-ethanamine (2.580 g) in ethyl acetate (26 ml). After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (2.269 g) as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-d1fc18cbc12f48179fdf73f4c121d134
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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