Hydrogen chloride-ethyl acetate → HCID 22013762, compound

HRID 1532688Notes

Reaction equation

HRID 1532688 reaction equation
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:47])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:47][N:9]([CH3:8])[CH2:10][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][C:20]([C:22]([NH:24][CH3:25])=[O:23])=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46]

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013763HCID 22013763, compound

Product 1

HCID 22013762HCID 22013762, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.89 ml) was added to a solution containing 1-[3-(dimethylamino)propyl]-2-henicosyl-N-methyl-1H-benzimidazole-5-carboxamide (1.818 g) in a mixture of ethyl acetate (18 ml) and ethanol (1.8 ml). After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.611 g) as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-7c4bd62862fc49ad97d6b1d408b68261
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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