1-Heptanamine → HCID 22633583, compound

HRID 1532718Notes

Reaction equation

[CH2:1]([NH2:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[C:9]1(=[O:16])[O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH2:1]([NH:8][C:14](=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][OH:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

Reactant 2

HCID 81271-Heptanamine

HCID 10401epsilon-CAPROLACTONE

Product 1

HCID 22633583HCID 22633583, compoundYield 78%

Conditions

Temperature: 100 °C

Procedure

A mixture of n-heptylamine (1.21 g, 10.5 mmols) and 6-hexanolactone (1.14 g, 10 mmols) was stirred at 100° C. for 3 hours, and then crystallized from ether-hexane to obtain 1.77 g (yield 78%) of N-heptyl-6-hydroxyhexaneamide as colorless crystal.

Workup

customcrystallized from ether-hexane

Sources & evidence

ORD record: ord-d545483b69654ad080f73b955994bb02
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06204278B1

Reaction notes

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