Lithium hydroxide, monohydrate → HCID 131722460, compound

HRID 1532878Notes

Reaction equation

HRID 1532878 reaction equation
C[O:2][C:3](=[O:41])[C@H:4]([CH2:37][CH2:38][S:39][CH3:40])[NH:5][C:6](=[O:36])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]([O:19][CH:20]([CH2:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH3:21])[S:14][CH2:15][CH2:16][CH2:17][CH3:18])=[CH:9][C:8]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH3:35].O.[OH-].[Li+:44]>>[Li+:44].[CH2:15]([S:14][CH:13]([O:19][CH:20]([CH2:22][CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1)[CH3:21])[C:10]1[CH:11]=[CH:12][C:7]([C:6]([NH:5][C@H:4]([C:3]([O-:41])=[O:2])[CH2:37][CH2:38][S:39][CH3:40])=[O:36])=[C:8]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH3:35])[CH:9]=1)[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 70225548HCID 70225548, compound

Product 1

HCID 131722460HCID 131722460, compound

Procedure

The product from Example 1312C (242 mg, 0.4 mmol) was allowed to react with lithium hydroxide monohydrate (18 mg, 0.42 mmol) in a manner similar to that described in Example 608E to afford the title compound. 1H NMR (DMSO-d6, 300 MHz) δ0.73-0.93 (m, 2H), 0.82 (t, J=7 Hz, 3H), 1.02-1.74 (m, 20H), 1.77-2.02 (m, 6H), 2.15 (m, 1H), 2.59 (dd, J=6.5, 13 Hz, 1H), 2.72 (dd, J=4.5, 13 Hz, 1H), 3.55-3.73 (m, 2H), 4.51 (d, J=12.5 Hz, 1H), 4.65 (d, J=12.5 Hz, 1H), 6.95 (m, 1H), 7.10-7.25 (m, 4H), 7.37 (d, J=7.5 Hz,1H), 7.53 (d, J=8 Hz, 1H); MS (APCI(−)) m/z: (M−H)− 584; Anal. Calcd for C33H46LiNO4S2.0.85 H2O: C, 65.29; H, 7.92; N, 2.31. Found: C, 65.29; H, 7.45; N, 2.15.

Sources & evidence

ORD record
ord-bb885f5528234a9e92c157a4d86f940d
Source dataset
uspto-grants-2001_03
Patent number
US06204293B1

Reaction notes

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