3-Aminopyridine → HCID 44531689, compound

HRID 1532968Notes

Reaction equation

HRID 1532968 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[C:17]3[CH:25]=[C:24]([C:26]4[O:30][C:29]([CH:31]=O)=[CH:28][CH:27]=4)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:33][C:34]1[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[C:17]3[CH:25]=[C:24]([C:26]4[O:30][C:29]([CH2:31][NH:33][C:34]5[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=5)=[CH:28][CH:27]=4)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 100093-AminopyridineHCID 219520464-(4-Benzyloxyanilino)-6-(5-formylfuran-2-yl) pyrido[3,4-d]pyrimidine

Product 1

HCID 44531689HCID 44531689, compound

Procedure

In an analogous manner to Example 1, 5-(4-(4-Benzyloxy-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl)-furan-2-carbaldehyde and 3-aminopyridine were converted into the title compound; δH [2H6]-DMSO 10.42 (1H, b), 9.08 (1H, s), 8.69 (1H, s), 8.55 (1H, s), 8.09 (1H, d), 7.79 (1H, d), 7.70 (2H, d), 7.52−7.27 (5H, m), 7.16−6.99 (5H, m), 6.52 (2H, m), 5.11 (2H, s), 4.42 (2H, d); m/z 501 (M+1)+.

Sources & evidence

ORD record
ord-f9a5714665fe43b2acc601f262353a1f
Source dataset
uspto-grants-2001_03
Patent number
US06207669B1

Reaction notes

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