3-{[(4-Chlorophenyl)methyl]amino}propan-1-ol → HCID 11150002, compound

HRID 1532983Notes

Reaction equation

HRID 1532983 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][O:11][CH:10]([CH2:15][Cl:16])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17]C1C=CC(CNCCCO)=CC=1>>[Cl:17][C:5]1[CH:4]=[CH:3][C:2]([CH2:1][N:8]2[CH2:14][CH2:13][CH2:12][O:11][CH:10]([CH2:15][Cl:16])[CH2:9]2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 33825993-{[(4-Chlorophenyl)methyl]amino}propan-1-olHCID 103993654-Benzyl-2-(chloromethyl)-1,4-oxazepane

Product 1

HCID 11150002HCID 11150002, compoundYield 29%

Procedure

(±)-4-(4-Chlorobenzyl)-2-(chloromethyl)perhydro-1,4-oxazepin was prepared analogously to the method for the preparation of (±)-4-benzyl-2-(chloro-methyl)perhydro-1,4-oxazepin described in K. Araki et al. J. Med. Chem. 36, 1356 (1993), using N-(4-Chlorobenzyl)-N-(3-hydroxypropyl)amine as starting material. Yield 29%.

Sources & evidence

ORD record
ord-166e027e82484b3bb22248ad1cce6d3f
Source dataset
uspto-grants-2001_03
Patent number
US06207662B1

Reaction notes

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