Water → Phenol, 5-chloro-2-methoxy-

HRID 1532986Notes

Reaction equation

HRID 1532986 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6](B(O)O)[CH:7]=1.[OH2:13]>OO.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6]([OH:13])[CH:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 27357515-Chloro-2-methoxyphenylboronic acid

Product 1

HCID 588774Phenol, 5-chloro-2-methoxy-

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 784Hydrogen PeroxideSolvent

Procedure

A solution of 5-chloro-2-methoxy benzeneboronic acid (1.9 g, 10 mmol) in hydrogen peroxide (2.04 ml, 30% solution) and ethanol 40 ml was refluxed for 30 min. Water was added and the product was extracted with two portions of ethylacetate. Drying over magnesium sulfate and evaporation of the solvent gave the product as an oil. Yield 1.05 g, 65%.

Workup

  1. extractionthe product was extracted with two portions of ethylacetate
  2. dry with materialDrying over magnesium sulfate and evaporation of the solvent

Sources & evidence

ORD record
ord-3b47cfaa33fd4db0b1cbf0ace6029acd
Source dataset
uspto-grants-2001_03
Patent number
US06207662B1

Reaction notes

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