Magnesium → HCID 22012180, compound

HRID 1533011Notes

Reaction equation

HRID 1533011 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[CH:15]=1.[Mg]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:6]=2[CH:15]=1

Participants

3

Reactant 2

HCID 5462224MagnesiumHCID 22012191HCID 22012191, compound

Product 1

HCID 22012180HCID 22012180, compound

Procedure

The title compound was-prepared from 3-(5-fluorobenzofuran-3-yl) propionic acid (3 g) and spiro(isobenzofuran-1(3H),4′-piperidine] (2 g) by the method described in EXAMPLE 12. 3-(5-Fluoro-benzofuran-3-yl)-propionic acid was prepared by a procedure similar to the preparation of 3-(2,3-dihydro-5-fluorobenzofuran-3-yl)-propionic acid as described in EXAMPLE 11, but omitting the reduction with magnesium turnings. The title compound, 8, crystallized as the oxalate salt from acetone by addition of oxalic acid. Yield: 2.6 g, mp: 157-59° C.

Workup

  1. customThe title compound, 8, crystallized as the oxalate salt from acetone by addition of oxalic acid

Sources & evidence

ORD record
ord-a2a6710ebf52496bac68aa48177b8610
Source dataset
uspto-grants-2001_03
Patent number
US06207677B1

Reaction notes

Loading…