反应详情

温度

45 °C

To a solution of methyl (2-benzyloxyphenyl)acetate (935 mg) in tetrahydrofuran (9.4 ml) was added sodium borohydride (600 mg) and the suspension was heated to 45° C. A mixture of methanol (3 ml) and tetrahydrofuran (6 ml) was added dropwise to the mixture and the mixture was stirred for 2 hours. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane and quenched by 1 N aqueous hydrochloric acid solution. The organic layer was washed with brine, dried and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel [eluting with ethyl acetate - n-hexane (1:1)] to afford 2-(2-benzyloxyphenyl)ethanol (764 mg).

1. additionwas added dropwise to the mixture
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutionThe residue was dissolved in dichloromethane
4. customquenched by 1 N aqueous hydrochloric acid solution
5. washThe organic layer was washed with brine
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was purified by column chromatography on silica gel [eluting with ethyl acetate - n-hexane (1:1)]