HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanecarboxaldehyde → methyl (2RS,3SR)-3-cyclohexyl-3-hydroxy-2-(2-methoxyphenylmethyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanecarboxaldehyde | HCID 16275 | — |
| Reactant | Methyl 3-(2-methoxyphenyl)propanoate | HCID 562482 | — |
| Product | methyl (2RS,3SR)-3-cyclohexyl-3-hydroxy-2-(2-methoxyphenylmethyl)propionate | HCID 86756557 | — |
Reaction Steps
Methyl 3-(2-methoxyphenyl)propionate (1.80 g) was reacted with cyclohexane carbaldehyde (1.25 g) in substantially the same manner as that of Preparation 1-4) to give less polar isomer of methyl (2RS,3SR)-3-cyclohexyl-3-hydroxy-2-(2-methoxyphenylmethyl)propionate (isomer A) (0.706 g) and more polar isomer of (2RS,3RS)-isomer of the same (isomer B) (0.940 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06207686B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-b579cc72c7254289bcada1ed93f3570d |
| Source note | uspto-grants-2001_03 |