反应详情

Progress of the reaction is monitored by thin layer chromatography (Silica gel plates, eluent methylene chloride; visualization by dipping in a solution of 5% anisaldehyde in ethanol and heating). When the reaction is complete as judged by thin layer chromatography, the reaction mixture is adjusted to a pH of 13 with 10 M sodium hydroxide and then extracted 3 times with 250 ml of methylene chloride. The pH of the aqueous mixture is then adjusted to 3 with concentrated HCl, followed by continuous extraction with 1 liter of ethyl acetate for 24 hours. The ethyl acetate extract is dried over anhydrous magnesium sulfate and evaporated under reduced pressure to yield (R)-2-phenylbutyrolactone as a yellowish solid.

1. temperatureheating)
2. extractionextracted 3 times with 250 ml of methylene chloride
3. extractionfollowed by continuous extraction with 1 liter of ethyl acetate for 24 hours
4. extractionThe ethyl acetate extract
5. dry with materialis dried over anhydrous magnesium sulfate
6. customevaporated under reduced pressure