反应详情

温度

80 °C

To a solution of 2-chloro-4-nitro-1H-benzimidazole (300 mg) in N-methyl-2-pyrrolidone (4 ml) was added imidazole (517 mg) and the mixture was stirred at 80° C. for 8 hours. The reaction mixture was poured into brine and extracted with a mixture of chloroform and methanol. The organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel eluting with a mixture of chloroform and methanol (100-0-30-1) to give 2-(1-imidazolyl)-4-nitro-1H-benzimidazole (175 mg).

1. extractionextracted with a mixture of chloroform and methanol
2. dry with materialThe organic layer was dried over magnesium sulfate
3. customevaporated in vacuo
4. customThe residue was chromatographed on silica gel eluting with a mixture of chloroform and methanol (100-0-30-1)