Isopropylamine → HCID 19911141, compound

HRID 1533833Notes

Reaction equation

HRID 1533833 reaction equation
[O:1]=[C:2]1[CH:7]([C:8](=O)[CH2:9][CH3:10])[C:6](=[O:12])[CH2:5][CH:4]([C:13]#[N:14])[CH2:3]1.[CH:15]([NH2:18])([CH3:17])[CH3:16]>O1CCCC1>[O:1]=[C:2]1[CH:7]([C:8](=[N:18][CH:15]([CH3:17])[CH3:16])[CH2:9][CH3:10])[C:6](=[O:12])[CH2:5][CH:4]([C:13]#[N:14])[CH2:3]1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 19774688HCID 19774688, compound

Product 1

HCID 19911141HCID 19911141, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.2 g (0.006 mol) of 3,5-dioxo-4-propionylcyclohexanenitrile were dissolved in 40 ml of dry tetrahydrofuran, and 0.4 g (0.006 mol) of isopropylamine was added. The mixture was stirred for 16 hours at room temperature, the solvent was stripped off under reduced pressure and the residue was filtered under suction over a little silica gel using methylene chloride/methanol. The solvent was stripped off to give 1.3 g 92% of theory) of 3,5-dioxo-4-(1-isopropyliminopropyl)-cyclohexanenitrile.

Workup

  1. filtrationthe residue was filtered under suction over a little silica gel

Sources & evidence

ORD record
ord-833ebad1598644be8f4b7527b2d26000
Source dataset
uspto-grants-1992_02
Patent number
US05085689

Reaction notes

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