反应详情

To a solution of ethyl-3-(tetrahydro-2H-pyran-3-yl)propionate (3.0 g) was, at -78° C., added dropwise DIBAL (16 ml of 1.5 mole toluene solution) under a nitrogen atmosphere. Stirring was continued for one hour. The reaction was quenched by adding a methanol-water mixture. The resulting solution was allowed to warm up to room temperature. The solids which formed were removed. The filtrate was dried over magnesium sulfate and concentrated to yield a crude oil. The crude product was purified by distillation to yield 2.0 g of the title compound.

1. customwas, at -78° C.
2. customThe reaction was quenched
3. additionby adding a methanol-water mixture
4. customThe solids which formed
5. customwere removed
6. dry with materialThe filtrate was dried over magnesium sulfate
7. concentrationconcentrated
8. customto yield a crude oil
9. distillationThe crude product was purified by distillation