HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 5-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-Methoxyphenyl)piperazine | HCID 269722 | — |
| Reactant | 5-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one | HCID 14698746 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinone | HCID 15030070 | 63% |
Reaction Steps
This compound was prepared according to the procedure of Example 2. A mixture of 2.4 g (0.012 mol) of 1-(4-methoxyphenyl)piperazine, 2.0 g (0.012 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 4.2 g (0.04 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 2.4 g (63%) of pink solid, mp 103°-104° C. (2-propanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05086055 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-f1226ce31da14a6aa7fe2ae81724d835 |
| Source note | uspto-grants-1992_02 |