Potassium Iodide → 5-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinone

HRID 1533910Notes

Reaction equation

HRID 1533910 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl[CH2:16][CH2:17][CH:18]1[O:22][C:21](=[O:23])[N:20]([CH3:24])[CH2:19]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC.CC(O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:16][CH2:17][CH:18]3[O:22][C:21](=[O:23])[N:20]([CH3:24])[CH2:19]3)[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 2697221-(4-Methoxyphenyl)piperazineHCID 146987465-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one

Product 1

HCID 150300705-[2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinoneYield 63%

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 3776IsopropanolSolvent

Procedure

This compound was prepared according to the procedure of Example 2. A mixture of 2.4 g (0.012 mol) of 1-(4-methoxyphenyl)piperazine, 2.0 g (0.012 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 4.2 g (0.04 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 2.4 g (63%) of pink solid, mp 103°-104° C. (2-propanol).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f1226ce31da14a6aa7fe2ae81724d835
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Reaction notes

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