Potassium Iodide → HCID 86745447, compound

HRID 1533917Notes

Reaction equation

HRID 1533917 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].Cl[CH2:19][CH2:20][CH:21]1[O:25][C:24](=[O:26])[N:23]([CH3:27])[CH2:22]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+].[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40]>C(O)CCC>[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:19][CH2:20][CH:21]3[O:25][C:24](=[O:26])[N:23]([CH3:27])[CH2:22]3)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[C:14]([F:15])([F:17])[F:16]

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 444972Fumaric AcidHCID 27781371-(4-Chloro-3-(trifluoromethyl)phenyl)piperazineHCID 146987465-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one

Product 1

HCID 86745447HCID 86745447, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 2. A mixture of 4.0 g (0.15 mol) of 1-(4-chloro-3-trifluoromethylphenyl)piperazine (Emka-Chemie), 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave a gum as residue. The gum was converted to the fumaric acid salt and the solid was recrystallized from 95% ethanol to yield 5.7 g (78%) of white solid, mp 198°-201° C. (dec.).

Workup

  1. customThis compound was prepared
  2. customgave a gum as residue
  3. customthe solid was recrystallized from 95% ethanol

Sources & evidence

ORD record
ord-49a011ed87944ab0a91c24a061e9e986
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Reaction notes

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