Potassium Iodide → 5-[2-[4-(3,4-Dimethoxyphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-Oxazolidinone

HRID 1533922Notes

Reaction equation

HRID 1533922 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl[CH2:18][CH2:19][CH:20]1[O:24][C:23](=[O:25])[N:22]([CH3:26])[CH2:21]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC.CC(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]2[CH2:12][CH2:13][N:14]([CH2:18][CH2:19][CH:20]3[O:24][C:23](=[O:25])[N:22]([CH3:26])[CH2:21]3)[CH2:15][CH2:16]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 27362071-(3,4-Dimethoxyphenyl)piperazineHCID 146987465-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one

Product 1

HCID 150300865-[2-[4-(3,4-Dimethoxyphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-OxazolidinoneYield 42%

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 3776IsopropanolSolvent

Procedure

This compound was prepared according to the procedure of Example 2. A mixture of 3.3 g (0.015 mol) of 1-(3,4-dimethoxyphenyl)piperazine, 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 mL of 1-butanol gave 2.2 g (42%) of white solid, mp 90°-92° C. (2-propanol).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-8a4f82744887470d9c5e937323b67f63
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Reaction notes

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