Chloroform → HCID 15623851, compound

HRID 1534022Notes

Reaction equation

HRID 1534022 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([Cl:10])[C:7]([NH2:11])=[C:6]([Br:12])[CH:5]=1)(=[O:3])[CH3:2].C(Cl)(Cl)[Cl:14]>>[NH2:11][C:7]1[C:8]([Cl:10])=[N:9][C:4]([C:1](=[O:3])[CH2:2][Cl:14])=[CH:5][C:6]=1[Br:12]

Participants

3

Reactant 2

HCID 6212Chloroform2×HCID 15623852HCID 15623852, compound

Product 1

HCID 15623851HCID 15623851, compound

Procedure

0.8 g (3.2 mmol) of 6-acetyl-3-amino-4-bromo-2-chloro-pyridine are dissolved in 5 ml of CHCl3, and 462 mg (3.42 mmol) of SO2Cl2, dissolved in 5 ml of CHCl3, are added. The mixture is stirred at room temperature for 30 minutes and then poured onto NaHCO3 solution and extracted with CH2Cl2.

Workup

  1. additionare added
  2. additionpoured onto NaHCO3 solution
  3. extractionextracted with CH2Cl2

Sources & evidence

ORD record
ord-f5e6427b8a2c45c4994f63c98aaa1a10
Source dataset
uspto-grants-1992_02
Patent number
US05086181

Reaction notes

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