反应详情

The product of Example 60 was added to methyl ethyl ketcne (50 ml), K2CO3 (5 g) and methyl iodide (5 ml) then heated at reflux for 4 1/2 hrs. The reaction was cooled, H2O added, followed by an EtOAc extraction. The organic layer was separated, washed with brine, dried (Na2SO4), filtered and evaporated. Trituration of the residue afforded the desired compound after filtration, m.p. 129° C.-30° C.

1. temperaturethen heated
2. temperatureat reflux for 4 1/2 hrs
3. temperatureThe reaction was cooled
4. extractionfollowed by an EtOAc extraction
5. customThe organic layer was separated
6. washwashed with brine
7. dry with materialdried (Na2SO4)
8. filtrationfiltered
9. customevaporated