4-(Thiophen-2-yl)pyrrolidin-2-one → 3-(Thiophen-2-yl)pyrrolidine

HRID 1534045Notes

Reaction equation

HRID 1534045 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]1[CH2:16][NH:15][C:14](=O)[CH2:13]1>C1COCC1>[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]1[CH2:13][CH2:14][NH:15][CH2:16]1

Participants

4

Reactant 2

HCID 111595394-(Thiophen-2-yl)pyrrolidin-2-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 150299073-(Thiophen-2-yl)pyrrolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of LiAlH4 (0.46 g) in THF (25 ml) was added the product of Example 134 (1.0 g) in THF (30 ml). After the addition was complete the reaction was heated at reflux for 4 hrs.

Workup

  1. additionAfter the addition
  2. temperaturewas heated
  3. temperatureat reflux for 4 hrs

Sources & evidence

ORD record
ord-1bd9e3476aad4be895f62fe85d98a6bf
Source dataset
uspto-grants-1992_02
Patent number
US05086074

Reaction notes

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