Sodium Hydroxide → HCID 9976684, compound

HRID 1534088Notes

Reaction equation

HRID 1534088 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:17][CH:16]([N:18](CC)[C:19](=O)[C:20](F)(F)F)[CH2:15]4)[CH:12]=3)[C:7](=[O:28])[C:6]3[C:29](=[O:32])[NH:30][S:31][C:5]2=3)[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:27])=[C:11]([N:14]4[CH2:15][CH:16]([NH:18][CH2:19][CH3:20])[CH2:17]4)[CH:12]=3)[C:7](=[O:28])[C:6]3[C:29](=[O:32])[NH:30][S:31][C:5]2=3)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 10389972HCID 10389972, compound

Product 1

HCID 9976684HCID 9976684, compound

Procedure

By a procedure completely analogous to that described in Example 2, 9-cyclopropyl-6-fluoro-7-{3-[N-(ethyl)trifluoroacetamido]-1-azetidinyl}-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione, melting point 256°-259° C., is obtained, which product is hydrolyzed by heating it with 10% sodium hydroxide for 2 hours; 9-cyclopropyl-6-fluoro-7-(3-ethylamino-1-azetidinyl)-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione, melting point 231°-236° C., is obtained.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-7c4ac2cc6dd040c9a4bac9508ac7ab80
Source dataset
uspto-grants-1992_02
Patent number
US05087621

Reaction notes

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