Sodium Hydroxide → HCID 9976684, compound

Participants

Reaction Steps

By a procedure completely analogous to that described in Example 2, 9-cyclopropyl-6-fluoro-7-{3-[N-(ethyl)trifluoroacetamido]-1-azetidinyl}-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione, melting point 256°-259° C., is obtained, which product is hydrolyzed by heating it with 10% sodium hydroxide for 2 hours; 9-cyclopropyl-6-fluoro-7-(3-ethylamino-1-azetidinyl)-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione, melting point 231°-236° C., is obtained.

Provenance & Evidence