反应详情

The wet mixture of 2-acetylamino-3-nitrotoluene (4) and 2-acetylamino-5-nitrotoluene as obtained in Preparation Example 1 was placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid was added thereto. Immediately on heating and boiling, the mixture was hydrolyzed. The boiling was continued until 36 l of a distillate was collected. On cooling the distillate, there was obtained 2-amino-3-nitrotoluene (5) as an orange needle-like crystal having a melting point of 92.8° to 93.2° C. in a percent yield of 46%.

1. customas obtained in Preparation Example 1
2. distillationwas placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid
3. additionwas added
4. temperatureImmediately on heating
5. customwas collected
6. temperatureOn cooling the distillate, there