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HRID1534195

反应详情

EQUATION

反应方程式

HRID 1534195 的结构方程式

REACTANTS

反应物

2
结构：C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@H](C)C(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
HCID9547243

Ercalcitriol

C28H44O3

结构：C[C@H](/C=C/[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)C[C@H](O)[C@]4(C)[C@H]3CC[C@]12C
HCID67831887

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CC1=C(/C=C\C2=CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)CC1
HCID5281058

Previtamin D3

C27H44O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CCOCC
溶剂HCID21868444

未命名化合物

PROCEDURE

实验过程

(22E)-5,7,22-Ergostatriene-1α,3β,25-triol and its 24-epimer of formula (I) can be converted into 1α,25-dihydroxyvitamin D2 and its 24-epimer of formula (II) by a general procedure for the synthesis of vitamin D from the 5,7-diene. More particularly, (22E)-5,7,22-ergostatriene-1α,3β,25-triol and its 24-epimer of formula (I) in tetrahydrofuran/ether were respectively irradiated to afford a previtamin D. The previtamin D was isomerized by heating in a suitable solvent, e.g. ethanol. Purification of the resulting products by chromatography and recrystallization affords 1α,25-dihydroxyvitamin D2 and the 24-epimer thereof.