1alpha,25-Dihydroxyvitamin D2 → Previtamin D3

참여 물질

반응 단계

(22E)-5,7,22-Ergostatriene-1α,3β,25-triol and its 24-epimer of formula (I) can be converted into 1α,25-dihydroxyvitamin D2 and its 24-epimer of formula (II) by a general procedure for the synthesis of vitamin D from the 5,7-diene. More particularly, (22E)-5,7,22-ergostatriene-1α,3β,25-triol and its 24-epimer of formula (I) in tetrahydrofuran/ether were respectively irradiated to afford a previtamin D. The previtamin D was isomerized by heating in a suitable solvent, e.g. ethanol. Purification of the resulting products by chromatography and recrystallization affords 1α,25-dihydroxyvitamin D2 and the 24-epimer thereof.

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