Potassium Carbonate → HCID 14570912, compound

HRID 1534252Notes

Reaction equation

HRID 1534252 reaction equation
C([O:4][C:5]1[CH:29]=[CH:28][C:8]([CH2:9][C:10]2[O:11][C:12]3[C:19]([Cl:20])=[CH:18][C:17]([CH2:21][CH2:22][CH3:23])=[C:16]([O:24][C:25](=[O:27])[CH3:26])[C:13]=3[C:14]=2[CH3:15])=[CH:7][CH:6]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:4][C:5]1[CH:29]=[CH:28][C:8]([CH2:9][C:10]2[O:11][C:12]3[C:19]([Cl:20])=[CH:18][C:17]([CH2:21][CH2:22][CH3:23])=[C:16]([O:24][C:25](=[O:27])[CH3:26])[C:13]=3[C:14]=2[CH3:15])=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 14570911HCID 14570911, compound

Product 1

HCID 14570912HCID 14570912, compoundYield 79.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-(p-acetoxybenzyl)-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran (150 mg, 0.36 mmole) in methanol 5 mL) and a saturated solution of potassium carbonate (3 mL) was stirred at room temperature for 5 minutes. The reaction was poured in water, extracted with methylene chloride, washed with brine, dried (Na2SO4), and concentrated in vacuo to yield 107 mg (79%) of 2-(p-hydroxybenzyl)-3-methyl-4-acetoxy-5-propyl-7-chlorobenzofuran.

Workup

  1. extractionextracted with methylene chloride
  2. washwashed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-88fa25255a5f48e8b50a2368a362f930
Source dataset
uspto-grants-1992_02
Patent number
US05087638

Reaction notes

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