HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 14495798, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Bromopentane | HCID 8057 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Reactant | HCID 178505636 | HCID 178505636 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14495798 | HCID 14495798 | — |
Reaction Steps
0.1 mol of pentyl bromide and subsequently 13 ml of DMPU are added dropwise to the solution of 1,2-difluorophenyl potassium in THF prepared according to 1c). After stirring below -85° C. for 60 minutes, the mixture is warmed in the course of 30 minutes to -40° C. and water is added at this temperature. The mixture is subsequently worked up as customary. b.p.30: 112 ° C. The following are prepared analogously:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05087764 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-214673d9528046ddb128f9e89fdad5e6 |
| Source note | uspto-grants-1992_02 |