Water → HCID 14495798, compound

HRID 1534263Notes

Reaction equation

HRID 1534263 reaction equation
[CH2:1](Br)[CH2:2][CH2:3][CH2:4][CH3:5].CN1C(=O)N(C)CCC1.[F:16][C:17]1([K])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]1[F:23].O>C1COCC1>[CH2:1]([C:19]1[C:18]([F:23])=[C:17]([F:16])[CH:22]=[CH:21][CH:20]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 80571-BromopentaneHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 178505636HCID 178505636, compound

Product 1

HCID 14495798HCID 14495798, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.1 mol of pentyl bromide and subsequently 13 ml of DMPU are added dropwise to the solution of 1,2-difluorophenyl potassium in THF prepared according to 1c). After stirring below -85° C. for 60 minutes, the mixture is warmed in the course of 30 minutes to -40° C. and water is added at this temperature. The mixture is subsequently worked up as customary. b.p.30: 112 ° C. The following are prepared analogously:

Workup

  1. customprepared
  2. additionis added at this temperature
  3. custom112 ° C
  4. customThe following are prepared analogously

Sources & evidence

ORD record
ord-214673d9528046ddb128f9e89fdad5e6
Source dataset
uspto-grants-1992_02
Patent number
US05087764

Reaction notes

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