Iodine → HCID 14495799, compound

HRID 1534264Notes

Reaction equation

HRID 1534264 reaction equation
[CH2:1]([C:6]1[C:7]([F:13])=[C:8]([F:12])[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[I:14]I.O>C(OCC)C>[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([I:14])=[C:8]([F:12])[C:7]=1[F:13])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 807IodineHCID 962WaterHCID 14495798HCID 14495798, compound

Product 1

HCID 14495799HCID 14495799, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
-70 °C

Procedure

3-Pentyl-1,2-difluorobenzene is metalated according to 1a) or 1b). A solution of 0.1 mol of iodine in 100 ml of diethyl ether is added slowly at -70° C. The mixture is subsequently stirred for a further hour at -70° C. and warmed to 0° C., and water is added to the solution. After washing with sodium hydrogen sulfite solution and dilute sodium hydroxide solution the mixture is worked up as customary.

Workup

  1. temperaturewarmed to 0° C.
  2. washAfter washing with sodium hydrogen sulfite solution and dilute sodium hydroxide solution the mixture

Sources & evidence

ORD record
ord-e2970eb7b58e4f429d72665fc09f6d4f
Source dataset
uspto-grants-1992_02
Patent number
US05087764

Reaction notes

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