HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperidinecarboxaldehyde → 4-Ethoxy-2,3-difluorobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperidinecarboxaldehyde | HCID 17429 | — |
| Reactant | HCID 178506739 | HCID 178506739 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Tetrahydrofuran hexane | HCID 21883165 | — |
| Product | 4-Ethoxy-2,3-difluorobenzaldehyde | HCID 14495625 | — |
Reaction Conditions
| Temperature | -20 °C |
|---|
Reaction Steps
A solution of 0.1 mol of N-formylpiperidine in 10 ml of THF is added dropwise at -60° C. to the solution of 4-ethoxy-2,3-difluorophenyllithium in THF/hexane prepared according to 1b). The mixture is then warmed to -20° C. in the course of 1 hour. Customary working up (recrystallization from petroleum ether (boiling range 40°-60° C.) gives colourless crystals, m.p. 70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05087764 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-fe5c786845334609ae9a8dd6913d87f5 |
| Source note | uspto-grants-1992_02 |