Potassium Carbonate → 2,2,3,3-Tetrafluorocyclobutyl isopropyl ether

HRID 1534279Notes

Reaction equation

HRID 1534279 reaction equation
[CH:1]([O:4][C:5]1[C:8]([F:10])([F:9])[C:7]([F:12])([F:11])[C:6]=1Cl)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>O.[C].[Pd]>[CH:1]([O:4][CH:5]1[CH2:6][C:7]([F:11])([F:12])[C:8]1([F:9])[F:10])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 199110632-Chloro-3,3,4,4-tetrafluorocyclobutenyl isopropyl ether

Product 1

HCID 199110622,2,3,3-Tetrafluorocyclobutyl isopropyl etherYield 55%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 962WaterSolvent

Procedure

30 g (0.132 mol) of 2-chloro-3,3,4,4-tetrafluorocyclobutenyl isopropyl ether and 20 g (0.145 mol) of potassium carbonate are hydrogenated over 10 g of palladium-carbon in 100 ml of water at 120° C. for 5 hours. The catalyst is filtered off and the filtrate is extracted with dichloromethane. After drying, 2,2,3,3-tetrafluorocyclobutyl isopropyl ether is obtained with a yield of 55%.

Workup

  1. filtrationThe catalyst is filtered off
  2. extractionthe filtrate is extracted with dichloromethane
  3. customAfter drying

Sources & evidence

ORD record
ord-63b1b9f108414560b8e2c0617ce95366
Source dataset
uspto-grants-1992_02
Patent number
US05087775

Reaction notes

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