反应详情

Into a mixture of methanol (10 ml) and tetrahydrofuran (14 ml), methyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate (0.6 g) was dissolved, and lN sodium hydroxide solution (2.5 ml) was added thereto. The reaction was carried out at room temperature while stirring for 2 hours. After removal of methanol and tetrahydrofuran by distillation, the aqueous layer was washed with dichloromethane (1 ml), made acidic with conc. hydrochloric acid and extracted with ethyl acetate. The extract was concentrated to remove ethyl acetate to give 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionic acid (0.44 g). Yield, 76%.

1. dissolutionwas dissolved
2. customwas carried out at room temperature
3. customAfter removal of methanol and tetrahydrofuran
4. distillationby distillation
5. washthe aqueous layer was washed with dichloromethane (1 ml)
6. extractionextracted with ethyl acetate
7. concentrationThe extract was concentrated
8. customto remove ethyl acetate