反应详情

Methanesulfonyl chloride (37 μl, 0.48 mmol) was added to a solution of 3-(1-aminotridecyl)-5-trimethylsilylfuran (134.6 mg, 0.4 mmol) and triethylamine (67 μl, 0.48 mmol) in dichloromethane (2 ml) at 0°. Stirring continued overnight (14 hours) while the cooling both attained room temperature. The reaction mixture was quenched with water. Extraction (ethyl ether) and evaporation of the dried (magnesium sulfate) extracts gave an oil, which was purified by flash chromatography on silica using 10% ethyl ether/hexane. Fractions with Rf of about 0.07 on evaporation gave the title sulfonamide as a pale yellow oil.

1. customThe reaction mixture was quenched with water
2. extractionExtraction (ethyl ether) and evaporation of the
3. dry with materialdried (magnesium sulfate)
4. customextracts gave an oil, which
5. customwas purified by flash chromatography on silica using 10% ethyl ether/hexane
6. customFractions with Rf of about 0.07 on evaporation