2-Cyano-4-methylpyridine → (4-Methylpyridin-2-yl)methanamine

HRID 1534434Notes

Reaction equation

HRID 1534434 reaction equation
[C:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)#[N:2]>CO.N.[Ni]>[NH2:2][CH2:1][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 1

HCID 887392-Cyano-4-methylpyridine

Product 1

HCID 15144432(4-Methylpyridin-2-yl)methanamine

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

g 2 (0.0169 moles) of 2-cyano-4-methyl pyridine [J. Am. Chem. Soc. 78, 5842-5843 (1956)] dissolved in 400 ml of methanol containing 12% W/W of ammonia, were hydrogenated on 2 g of Ni-Raney at room temperature and 20 psi, until the theoretical amount of hydrogen was consumed.

Workup

  1. custom20 psi, until the theoretical amount of hydrogen was consumed

Sources & evidence

ORD record
ord-90ba9699cfbd43dd8d89473c0b7be1d6
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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