2-(3,4-Dichlorophenyl)acetyl chloride → HCID 131717173, compound

HRID 1534435Notes

Reaction equation

HRID 1534435 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH:4]([CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:3]1.[Cl:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](Cl)=[O:24])[CH:18]=[CH:19][C:20]=1[Cl:21]>>[OH2:24].[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([N:5]2[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH:4]2[CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[O:24])[CH:18]=[CH:19][C:20]=1[Cl:21].[Cl:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([N:5]2[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH:4]2[CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[O:24])[CH:18]=[CH:19][C:20]=1[Cl:21].[ClH:14]

Participants

3

Reactant 2

HCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 15165785HCID 15165785, compound

Product 1

HCID 131717173HCID 131717173, compound

Procedure

g 1.4 (0.0077 moles) of 4-methyl-2-(1-pyrrolidinyl)methyl piperidine were reacted with g 2.1 (0.0093 moles) of 3,4-dichlorophenylacetyl chloride as described in Example 1. The oily residue so obtained (g 3.1) was chromatographed on 60 g of silica gel, eluting with CH2Cl2 containing increasing amounts of methanol (0.5 to 1.5%).

Workup

  1. customThe oily residue so obtained (g 3.1)
  2. customwas chromatographed on 60 g of silica gel
  3. washeluting with CH2Cl2 containing
  4. temperatureincreasing amounts of methanol (0.5 to 1.5%)

Sources & evidence

ORD record
ord-0f56e3c76dd5484bbc7cf972e3864923
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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