HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Pyrrolidin-1-yl)carbonyl-3-hydroxy piperidine → 2-(Pyrrolidin-1-yl)methyl-3-hydroxy piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Pyrrolidin-1-yl)carbonyl-3-hydroxy piperidine | HCID 15165787 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Pyrrolidin-1-yl)methyl-3-hydroxy piperidine | HCID 15123236 | 65.1% |
Reaction Steps
By reducing 5 g (0.025 moles) of 2-(pyrrolidin-1-yl)carbonyl-3-hydroxy piperidine, with 1.2 g (0.025 moles) of LiAlH4 in 100 ml of dry THF, using an alkaline work-up, 3 g of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05089507 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-98091e3b26e94aea9f31ab0b98eec4a9 |
| Source note | uspto-grants-1992_02 |