2-(Pyrrolidin-1-yl)carbonyl-3-hydroxy piperidine → 2-(Pyrrolidin-1-yl)methyl-3-hydroxy piperidine

HRID 1534440Notes

Reaction equation

HRID 1534440 reaction equation
[N:1]1([C:6]([CH:8]2[CH:13]([OH:14])[CH2:12][CH2:11][CH2:10][NH:9]2)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:1]1([CH2:6][CH:8]2[CH:13]([OH:14])[CH2:12][CH2:11][CH2:10][NH:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 151657872-(Pyrrolidin-1-yl)carbonyl-3-hydroxy piperidineHCID 21226445Aluminium lithium hydride

Product 1

HCID 151232362-(Pyrrolidin-1-yl)methyl-3-hydroxy piperidineYield 65.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By reducing 5 g (0.025 moles) of 2-(pyrrolidin-1-yl)carbonyl-3-hydroxy piperidine, with 1.2 g (0.025 moles) of LiAlH4 in 100 ml of dry THF, using an alkaline work-up, 3 g of the title compound were obtained.

Sources & evidence

ORD record
ord-98091e3b26e94aea9f31ab0b98eec4a9
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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