2H-Azepin-2-one, 3,3-dichlorohexahydro-5,5-dimethyl- → HCID 10607353, compound

HRID 1534449Notes

Reaction equation

HRID 1534449 reaction equation
[Cl:1][C:2]1(Cl)[CH2:8][C:7]([CH3:10])([CH3:9])[CH2:6][CH2:5][NH:4][C:3]1=[O:11].[H][H]>C(O)(=O)C.[Pd]>[Cl:1][CH:2]1[CH2:8][C:7]([CH3:9])([CH3:10])[CH2:6][CH2:5][NH:4][C:3]1=[O:11]

Participants

5

Reactant 2

HCID 106322272H-Azepin-2-one, 3,3-dichlorohexahydro-5,5-dimethyl-HCID 178418361HCID 178418361, compound

Product 1

HCID 10607353HCID 10607353, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

15.2 g (0.086 moles) of 3,3-dichloro-5,5-dimethyl-2-oxoperhydroazepine were dissolved in 900 ml of glacial acetic acid and shaked at 40 psi of hydrogen with 7 g of 10% Pd/C as in Description 14, to yield 13.6 g of the title compound.

Sources & evidence

ORD record
ord-0b81547c0d3a4d7d989b21fb64f1242c
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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