HCID 178450497, compound → HCID 10405519, compound

HRID 1534470Notes

Reaction equation

HRID 1534470 reaction equation
C([O:3][C:4](=O)[C:5]([C:24](=[O:28])[CH2:25][CH2:26][CH3:27])=[CH:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][O:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:10][CH:9]=1)C>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:24]([C:5]1[C:4](=[O:3])[C:9]2[C:8](=[CH:13][CH:12]=[C:11]([CH2:14][O:15][C:16](=[O:23])[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:10]=2)[NH:7][CH:6]=1)(=[O:28])[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 1

HCID 178450497HCID 178450497, compound

Product 1

HCID 10405519HCID 10405519, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Ethyl-2-butyryl-3-(4-benzoyloxymethylphenylamino)acrylate (50 g) was added portion wise to boiling diphenyl ether (500 ml) and heating continued under relfux for 30 minutes. On cooling, crystals started to appear and the mixture was diluted with petroleum ether to give 3-butyryl-6-(benzoyloxymethyl)4(1H)quinolone (39.7 g, 96%) as light brown crystals, m.p. 220° C.-3° C.

Workup

  1. temperatureheating
  2. temperatureOn cooling

Sources & evidence

ORD record
ord-92804ba8ddcf40baae86112db670f46b
Source dataset
uspto-grants-1992_02
Patent number
US05089504

Reaction notes

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