2-Amino-alpha-methylbenzenemethanol → HCID 178450483, compound

HRID 1534486Notes

Reaction equation

HRID 1534486 reaction equation
[OH:1][CH:2]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])[CH3:3].[C:11]([C:16](=[CH:22]OCC)[C:17]([O:19][CH2:20][CH3:21])=[O:18])(=[O:15])[CH2:12][CH2:13][CH3:14]>>[C:11]([C:16](=[CH:22][NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=1[CH:2]([OH:1])[CH3:3])[C:17]([O:19][CH2:20][CH3:21])=[O:18])(=[O:15])[CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 1120582-Amino-alpha-methylbenzenemethanolHCID 3359484Ethyl 2-butyryl-3-ethoxyacrylate

Product 1

HCID 178450483HCID 178450483, compoundYield 96.8%

Procedure

2-(1-hydroxyethyl)aniline (30 g, 0.32 mol) and ethyl 2-butyryl-3-ethoxyacrylate (47.3 g, 0.22 mol) were heated together on a rotary evaporator (bath temperature 100° C.) for 1 hour to give ethyl 2-butyryl-3-(2-(1-hydroxyethyl)-phenylamino)acrylate as an oil (65 g, 96%).

Sources & evidence

ORD record
ord-ffcd9c174d8a4962bf2dcdb8644d4fed
Source dataset
uspto-grants-1992_02
Patent number
US05089504

Reaction notes

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