反应详情

Ethyl 2-butyryl-3-(2-(1-benzoyloxyethyl)phenylamino)-acrylate (70 g, 0.17 mol) was added dropwise to boiling diphenyl ether (700 ml) keeping the reaction temperature above 240° C. The mixture was heated under reflux for 1 hour then cooled rapidly. The mixture was chromatographed (silica gel, dichloromethane +methanol (2%-4%)) to afford the required compound as a light solid (23.2 g, 56%) m.p. 206° C.-8° C.

1. customthe reaction temperature above 240° C
2. temperatureThe mixture was heated
3. temperatureunder reflux for 1 hour
4. temperaturethen cooled rapidly
5. customThe mixture was chromatographed (silica gel, dichloromethane +methanol (2%-4%))