Formaldehyde → HCID 19910071, compound

HRID 1534652Notes

Reaction equation

HRID 1534652 reaction equation
[BrH:1].Br.[CH2:3]([N:10]1[CH2:18][CH2:17][C:16]2[CH2:15][NH:14][CH2:13][C:12]=2[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:19]=O>C(O)=O>[BrH:1].[BrH:1].[CH2:3]([N:10]1[CH2:18][CH2:17][C:16]2[CH2:15][N:14]([CH3:19])[CH2:13][C:12]=2[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 19910069HCID 19910069, compound

Product 1

HCID 19910071HCID 19910071, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-Benzyl-3,8-diazabicyclo[4.3.0]non-1(6)-ene dihydrobromide (0.75 g) was refluxed in 85% formic acid (10 ml) and 37% formaline (7 ml) for 5 hours. The solvents were removed under reduced pressure and the solid was washed with isopropanol ethylether (2:1) to give 3-benzyl-8-methyl-3,8-diazabicyclo[4.3.0]non-1(6)-ene dihydrobromide (0.64 g, yield 82%).

Workup

  1. customThe solvents were removed under reduced pressure
  2. washthe solid was washed with isopropanol ethylether (2:1)

Sources & evidence

ORD record
ord-6d809993ea1241a1b96b6dfe7682800c
Source dataset
uspto-grants-1992_02
Patent number
US05089621

Reaction notes

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