反应详情

A mixture of 45 mL trifluoroacetic acid and mL water was chilled in an ice bath while 34 g (0.132 mole) of (9) was added with stirring. The resulting solution was allowed to warm to room temperature over 1.5 h and then evaporated under a slow nitrogen stream overnight. The residue was triturated with ether. The solid was filtered, rinsed well with ether and dried to yield 21 g of the title compound (10), mp 77°-78° C. Anal. Calcd. for C10H15NO4F3 : C, 44.28; H, 5.95; N, 5.16. Found: C, 4.07; H, 5.96; N, 5.09.

1. additionwas added
2. customevaporated under a slow nitrogen
3. customThe residue was triturated with ether
4. filtrationThe solid was filtered
5. washrinsed well with ether
6. customdried