Acetic Acid → HCID 19908383, compound

HRID 1534846Notes

Reaction equation

HRID 1534846 reaction equation
[N:1]([N:3]([C:8]([C:11]([NH:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])([CH3:10])[CH3:9])[NH:4][C:5](N)=[O:6])=[O:2].C(O)(=O)C>C(Cl)(Cl)Cl>[C:14]([NH:13][C:11]([C:8]([N:3]1[N:4]=[C:5]([O-:6])[O:2][NH2+:1]1)([CH3:10])[CH3:9])=[O:12])([CH3:17])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 21655031HCID 21655031, compound

Product 1

HCID 19908383HCID 19908383, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 12.0 g of the compound 4c), 30 ml of glacial acetic acid and 70 ml of chloroform is heated under reflux for 3 h. After cooling to room temperature, it is washed with sodium bicarbonate solution and with water, and the chloroform solution is dried using sodium sulphate and concentrated. The residue is recrystallized from tert-butyl methyl ether.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 3 h
  3. washit is washed with sodium bicarbonate solution and with water
  4. dry with materialthe chloroform solution is dried
  5. concentrationconcentrated
  6. customThe residue is recrystallized from tert-butyl methyl ether

Sources & evidence

ORD record
ord-90c595398ff1467cbd47e1ca2bc896ee
Source dataset
uspto-grants-1992_02
Patent number
US05091398

Reaction notes

Loading…