反应详情

Acetone azine (93 g) is added dropwise under reflux to a solution of propylmagnesium bromide, prepared from 44.3 g of magnesium and 224 g of propyl bromide in 350 ml of ether. After heating under reflux for 3 days, the mixture is poured into an ice-cooled aqueous ammonium chloride solution (500 ml) and the product is extracted using ether. The ether phase is concentrated, and the oily residue is stirred at room temperature for 2 h in 200 ml of water and 100 ml of conc. hydrochloric acid. The non-basic components are removed using tert-butyl methyl ether and the aqueous solution is concentrated on a rotary evaporator.

1. temperatureAfter heating
2. temperatureunder reflux for 3 days
3. extractionthe product is extracted
4. concentrationThe ether phase is concentrated
5. customThe non-basic components are removed
6. concentrationthe aqueous solution is concentrated on a rotary evaporator