Pyruvic Acid → HCID 67896391, compound

HRID 1534865Notes

Reaction equation

HRID 1534865 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([CH3:4])=[O:3].[F:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.[OH-].[K+:17]>CO>[F:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]=[CH:4][C:2](=[O:3])[C:1]([O-:6])=[O:5])=[CH:10][CH:9]=1.[K+:17]

Participants

5

Reactant 3

HCID 1060Pyruvic AcidHCID 14797Potassium HydroxideHCID 680234-Fluorobenzaldehyde

Product 1

HCID 67896391HCID 67896391, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of pyruvic acid and p-fluorobenzaldehyde (24.8 g) in methanol (20 ml) was cooled to 15° C. and treated with a solution of potassium hydroxide (16.8 g) in (50 ml) methanol. After 2/3 of the addition was complete, the cooling bath was removed and the temperature was allowed to rise to 40° C. A yellow precipitate appeared and was filtered after standing overnight. The solid was washed well with methanol and ether. The title compound (34.5 g) was used without further purification.

Workup

  1. additionAfter 2/3 of the addition
  2. customthe cooling bath was removed
  3. customto rise to 40° C
  4. filtrationwas filtered
  5. washThe solid was washed well with methanol and ether
  6. customThe title compound (34.5 g) was used without further purification

Sources & evidence

ORD record
ord-429b822558df4623954ca1545f402796
Source dataset
uspto-grants-1992_02
Patent number
US05091405

Reaction notes

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