Methyl iodide → HCID 14128693, compound

HRID 1534973Notes

Reaction equation

HRID 1534973 reaction equation
[N:1]([CH2:4][C:5]([CH2:9][N:10]=[N+:11]=[N-:12])([CH3:8])[CH2:6][OH:7])=[N+:2]=[N-:3].[CH3:13]I>O1CCOCC1>[CH3:13][O:7][CH2:6][C:5]([CH2:4][N:1]=[N+:2]=[N-:3])([CH2:9][N:10]=[N+:11]=[N-:12])[CH3:8]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 14128692HCID 14128692, compound

Product 1

HCID 14128693HCID 14128693, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

7.3 g (43 mmol) of compound 1 were dissolved in 50 ml of dioxane, and 7.2 g of potassium tert.-butylate were added. 6.71 g (47 mmol) of methyl iodide, dissolved in 20 ml of dioxane, were added dropwise to the mixture. After stirring at room temperature for 3 hours, the reaction batch was concentrated in vacuo. The resultant syrup was purified by chromatography over 70 g of silica gel (eluent: hexane/diisopropyl ether 5:1).

Workup

  1. additionwere added dropwise to the mixture
  2. concentrationthe reaction batch was concentrated in vacuo
  3. customThe resultant syrup was purified by chromatography over 70 g of silica gel (eluent: hexane/diisopropyl ether 5:1)

Sources & evidence

ORD record
ord-1b1d9222226943fd9c83d9be73d1c881
Source dataset
uspto-grants-1992_02
Patent number
US05091521

Reaction notes

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