Methyl iodide → HCID 14128693, compound

Participants

Reaction Steps

7.3 g (43 mmol) of compound 1 were dissolved in 50 ml of dioxane, and 7.2 g of potassium tert.-butylate were added. 6.71 g (47 mmol) of methyl iodide, dissolved in 20 ml of dioxane, were added dropwise to the mixture. After stirring at room temperature for 3 hours, the reaction batch was concentrated in vacuo. The resultant syrup was purified by chromatography over 70 g of silica gel (eluent: hexane/diisopropyl ether 5:1).

Provenance & Evidence