Imidazole → HCID 19908895, compound

HRID 1534992Notes

Reaction equation

HRID 1534992 reaction equation
[CH:1]12[O:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6]2.[NH:8]1[CH:12]=[CH:11][N:10]=[CH:9]1>C(O)C>[NH:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH:1]1[OH:7]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 9246Cyclohexene oxide

Product 1

HCID 19908895HCID 19908895, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of cyclohexene oxide (Va) (9.81 g), ethanol (25 ml) and imidazole (13.6 g) was refluxed under heating for 70 hours. The ethanol was evaporated and after addition of a small amount of water, the residue was extracted with chloroform. The extract was washed with a small amount of water, dried and evaporated to give 2-imidazolylcyclohexanol (IVa) (12.7 g) as crystaline residue (Yield 76%). Mp. 133°-134° C.

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 70 hours
  3. customThe ethanol was evaporated
  4. additionafter addition of a small amount of water
  5. extractionthe residue was extracted with chloroform
  6. washThe extract was washed with a small amount of water
  7. customdried
  8. customevaporated

Sources & evidence

ORD record
ord-b130f11aaa4449e5a2167349021930a7
Source dataset
uspto-grants-1992_02
Patent number
US05091539

Reaction notes

Loading…